The U.S. government has formally classified illicit fentanyl as a weapon of mass destruction through executive action. This policy shift highlights a critical global supply chain issue: the vast majority of contraband fentanyl entering U.S. borders originates from production and trafficking networks based in Mexico and China. The classification represents a significant tightening of enforcement measures and signals intensified international cooperation efforts to combat synthetic opioid proliferation. For the crypto and Web3 sectors, such geopolitical policy shifts often correlate with broader regulatory frameworks affecting cross-border transactions, compliance standards, and international financial oversight mechanisms.